MDPI - Publisher of Open Access Journals

16 pages, 2475 KiB

Open AccessReview

Plasma Treatment of Cellulose as the First Step in the Synthesis of Second-Generation Biofuel

by Gregor Primc and Miran Mozetič

Polymers 2025, 17(6), 782; https://doi.org/10.3390/polym17060782 (registering DOI) - 14 Mar 2025

Cellulosic ethanol has been an attractive biofuel for over a century. Despite the large scientific interest, the first step of treating cellulose before enzymatic hydrolysis is still inadequate, so the scientific community seeks innovative solutions. Among them, plasma treatment of raw cellulose represents [...] Read more.

Cellulosic ethanol has been an attractive biofuel for over a century. Despite the large scientific interest, the first step of treating cellulose before enzymatic hydrolysis is still inadequate, so the scientific community seeks innovative solutions. Among them, plasma treatment of raw cellulose represents an interesting approach. The literature on approaches to treat cellulose with gaseous plasma is surveyed, and the results reported by different authors are interpreted. Reactive gaseous particles like ions, electrons, metastables, and radicals interact chemically with the surface but do not cause significant depolymerization of bulk cellulose. Such depolymerization results from bond scission in the bulk cellulose by energetic plasma species capable of penetrating deep into the cellulose. Among them, photons in the range of vacuum ultraviolet radiation (photon energy above the threshold for bond scission) are the most suitable plasma species for the depolymerization of cellulose and the formation of water-soluble fragments, which are suitable for further treatment by enzymatic hydrolysis. Full article

(This article belongs to the Section Biobased and Biodegradable Polymers)

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13 pages, 1183 KiB

Open AccessArticle

The Italian Version of the New General Self-Efficacy Scale (NGSES): Structural Validity, Psychometric Properties, and Measurement Invariance

by Alessandro Alberto Rossi, Stefania Mannarini, Federica Taccini, Gianluca Castelnuovo and Giada Pietrabissa

J. Clin. Med. 2025, 14(6), 1988; https://doi.org/10.3390/jcm14061988 (registering DOI) - 14 Mar 2025

Abstract

Background/Objectives: General Self-Efficacy (GSE) refers to an individual’s belief in their overall ability to perform effectively across various situations. Research shows that GSE is a key predictor of multiple outcomes, including psychological resilience, better health, and improved overall well-being across different populations and [...] Read more.

Background/Objectives: General Self-Efficacy (GSE) refers to an individual’s belief in their overall ability to perform effectively across various situations. Research shows that GSE is a key predictor of multiple outcomes, including psychological resilience, better health, and improved overall well-being across different populations and environments. Numerous tools have been developed to measure GSE, enhancing our understanding of self-efficacy and its broader implications. This study aimed to evaluate the psychometric properties of the Italian version of the New General Self-Efficacy Scale (NGSES) in a community sample of adults recruited through social media platforms. Methods: The NGSES was adapted into Italian following the back-translation procedure. A total of 811 participants (mean = 43.18; 68.8% females) completed the scale. A confirmatory factor analysis (CFA) was used to examine the factorial structure of the questionnaire. Adjusted item-total correlations and internal consistency were assessed using McDonald’s omega. Additionally, multi-group CFA was used to test factorial invariance across gender. Results: The trimmed model exhibited a strong fit to the data: RMSEA = 0.068, CFI = 0.994, SRMR = 0.043. An omega coefficient of 0.872 confirmed the scale’s strong reliability. Convergent validity was established by a moderate and significant correlation with the NGSES. Configural, metric, scalar, and latent means invariance across genders were all confirmed. Conclusions: The NGSES was found to be a valid and reliable tool, suitable for both clinical and research applications in the Italian context. It can also inform the development of educational and therapeutic interventions aimed at enhancing GSE in the general population. Full article

(This article belongs to the Section Mental Health)

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12 pages, 239 KiB

Open AccessArticle

The Role of Adverse Childhood Experiences and Protective Factors in the Co-Occurrence of Somatization and Post-Traumatic Stress Symptoms

by Rubing Ma, Sizhe Chen and Jinjing Xiang

J. Mind Med. Sci. 2025, 12(1), 9; https://doi.org/10.3390/jmms12010009 (registering DOI) - 14 Mar 2025

Abstract

Objectives: Adverse childhood experiences (ACEs) pose a significant public health concern, negatively impacting children’s physical and mental health. This study examines the association between ACEs and the co-occurrence of somatization and post-traumatic stress symptoms (PTSSs) among Chinese college students. Additionally, it explores the [...] Read more.

Objectives: Adverse childhood experiences (ACEs) pose a significant public health concern, negatively impacting children’s physical and mental health. This study examines the association between ACEs and the co-occurrence of somatization and post-traumatic stress symptoms (PTSSs) among Chinese college students. Additionally, it explores the roles of both internal (psychological resilience) and external (social support) protective factors in this relationship. Methods: A sample of 701 students were analyzed using the Adverse Childhood Experiences International Questionnaire, the Somatization subscale from the Symptom Checklist-90, the PTSD Checklist from the DSM-5, the Connor–Davidson Resilience Scale, and the Multidimensional Scale of Perceived Social Support. A four-level outcome variable was created based on measures of somatization and PTSSs: no symptoms, somatization-only, post-traumatic stress symptoms-only (PTSSs-only), and co-occurring symptoms. Data analysis was conducted using multiple logistic regression. Results: Among Chinese college students, the prevalence of ACEs was 62.9%, while the prevalence of co-occurring somatization and PTSSs was 13.7%. The results of the multiple logistic regression analysis indicated a positive association between ACEs and the co-occurrence of somatization and PTSSs compared to no symptoms (OR = 2.28, p < 0.001). Furthermore, social support (OR = 0.26, p < 0.001) and psychological resilience (OR = 0.48, p = 0.049) were negatively associated with the co-occurrence. Conclusions: ACEs are risk factors for the co-occurrence of somatization and PTSSs among college students, while social support and psychological resilience serve as effective protective factors against this risk. Full article

19 pages, 2996 KiB

Open AccessReview

MYOSLID: A Critical Modulator of Cancer Hallmarks

by Kanupriya Medhi, Sagarika Mukherjee, Aastha Dagar, Ashutosh Kumar Tiwari, Sia Daffara, Sanjana Bana, Vivek Uttam, Md Rizwan Ansari, Vikas Yadav, Hardeep Singh Tuli and Aklank Jain

Genes 2025, 16(3), 341; https://doi.org/10.3390/genes16030341 (registering DOI) - 14 Mar 2025

Abstract

Despite being the leading cause of death worldwide, cancer still lacks precise biomarkers for effective targeting, limiting efforts to reduce mortality rates. This review explores the role and clinical significance of a newly identified long non-coding RNA, MYOSLID, in cancer progression. MYOSLID [...] Read more.

Despite being the leading cause of death worldwide, cancer still lacks precise biomarkers for effective targeting, limiting efforts to reduce mortality rates. This review explores the role and clinical significance of a newly identified long non-coding RNA, MYOSLID, in cancer progression. MYOSLID has emerged as a critical modulator in cancer progression by influencing key hallmarks such as proliferation, immune evasion, metastasis, and metabolic reprogramming. It promotes tumor cell growth by stabilizing hypoxia-inducible factor 1 and acting as a competing endogenous RNA (ceRNA) to sequester tumor-suppressive microRNAs like miR-29c-3p, thereby enhancing oncogene expression. It facilitates immune evasion by upregulating PD-L1, suppressing T cell activation, and modulating necroptosis pathways involving RIPK1 and RIPK3. Additionally, MYOSLID drives metastasis by regulating epithelial–mesenchymal transition markers such as LAMB3 and Slug while promoting RAB13-mediated cytoskeletal remodeling and enhancing cancer cell invasion. We have obtained the expression of MYOSLID from TCGA and the ENCORI database. The expression of colorectal adenocarcinoma (COAD) and head and neck squamous cell carcinoma (HNSCC) is associated with poor prognosis and lower survival rate. Given its significant potential as a diagnostic biomarker and therapeutic target, further research is required to elucidate its precise molecular mechanisms and therapeutic applications in cancer treatment. Full article

(This article belongs to the Special Issue Multifaceted Implications of Non-Coding RNAs in Cancer: From Biomarker Discovery to Therapeutic Target)

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22 pages, 4611 KiB

Open AccessArticle

Silk-Sericin Release from Polymeric Scaffold as Complementary Dermocosmetic Treatment for Acne

by Arianna Vargas González, Patricia Pérez Ramos, Eva María Pérez-Soriano, Francisco Javier Sola Dueñas, Denise Pérez Almazán, Jomarien García Couce and Gastón Fuentes Estévez

Polymers 2025, 17(6), 781; https://doi.org/10.3390/polym17060781 (registering DOI) - 14 Mar 2025

Abstract

Currently, acne therapy relies not only on specific drugs but also on complementary treatments, such as dermocosmetics. Several studies have reported the use of chitosan and alginate in scaffolds for drug delivery systems. These materials can be loaded with a product that exhibits [...] Read more.

Currently, acne therapy relies not only on specific drugs but also on complementary treatments, such as dermocosmetics. Several studies have reported the use of chitosan and alginate in scaffolds for drug delivery systems. These materials can be loaded with a product that exhibits anti-acne properties such as silk sericin, a protein with antioxidant, photoprotective, and moisturizing properties. Therefore, this study proposes the development of a chitosan/alginate scaffold, loaded with sericin, to serve as a dermocosmetic platform complementing the pharmacological treatment of acne. The moisture content of the alginate and chitosan was determined as 14.7 and 21%, respectively; the ash content, which is similar for both polymers, was approximately 5%. The employed chitosan had a deacetylation degree of 82%, as determined by infrared spectrometry and corroborated by potentiometry. This technique was also used to determine the mannuronic/guluronic ratio of the alginate [M/G = 1.3] and confirm the identity of each one of the polymers in the raw materials and the resulting scaffolds. The molecular weights of alginate, chitosan, and sericin were 85, 5.1, and 57.4 kDa, respectively. The pH [6.31] and total protein concentration of the sericin solution [c(SER) = 6.1 mg/mL] were determined using UV-visible spectrophotometry. Swelling and release studies indicated that, although there were varying degrees of cross-linking and certain variables to control, the mechanism that defines the nature of both processes (otherwise complementary) is the relaxation of the polymer chains. Full article

(This article belongs to the Topic Scientific Advances in STEM: Synergies to Achieve Success, 4th Volume)

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3 pages, 1089 KiB

Open AccessInteresting Images

A Second Residual Tooth Occurring from One Tooth: A Case Report

by Tatsuya Akitomo, Mariko Kametani, Yuko Iwamoto, Chieko Mitsuhata and Ryota Nomura

Diagnostics 2025, 15(6), 733; https://doi.org/10.3390/diagnostics15060733 - 14 Mar 2025

Abstract

In clinical pediatric dentistry, dental professionals may encounter some dental abnormalities. It may progress in various ways; therefore, long-term follow-up is essential. We describe the case of a 5-month-old male, and how the mandibular incisor was lost due to trauma. He was referred [...] Read more.

In clinical pediatric dentistry, dental professionals may encounter some dental abnormalities. It may progress in various ways; therefore, long-term follow-up is essential. We describe the case of a 5-month-old male, and how the mandibular incisor was lost due to trauma. He was referred to our hospital two days later, but the calcified tissue was detected in the oral cavity, confirming the residual tooth. We extracted the tooth, and a regular dental checkup revealed another residual tooth in the same region one year later. A residual tooth is considered to be affected by the Hertwig’s epithelial sheath, and it may occur when the root is immature. It is important for dental professionals to share this information and to continue long-term follow-up when they encounter patients at young ages who have had such teeth extracted or lost due to trauma. Full article

(This article belongs to the Section Medical Imaging and Theranostics)

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16 pages, 2559 KiB

Open AccessArticle

A Self-Adaptive Strip Pooling Network for Segmenting the Kidney Glomerular Basement Membrane

by Caifang Song, Xiangsheng Huang and Xiangyu Lyu

Sensors 2025, 25(6), 1829; https://doi.org/10.3390/s25061829 (registering DOI) - 14 Mar 2025

Abstract

Accurate semantic segmentation and automatic thickness measurement of the glomerular basement membrane (GBM) can aid pathologists in carrying out subsequent pathological diagnoses. The GBM has a complex ultrastructure and irregular shape, which makes it difficult to segment accurately. We found that the shape [...] Read more.

Accurate semantic segmentation and automatic thickness measurement of the glomerular basement membrane (GBM) can aid pathologists in carrying out subsequent pathological diagnoses. The GBM has a complex ultrastructure and irregular shape, which makes it difficult to segment accurately. We found that the shape of the GBM is striped, so we proposed an RSP model to extract both the strip and square features of the GBM. Additionally, grayscale images of the GBM are similar to those of surrounding tissues, and the contrast is low. We added an edge attention mechanism to further improve the quality of segmentation. Moreover, we revised the pixel-level loss function to consider the tissues around the GBM and locate the GBM as a doctor would, i.e., by using the tissues as the reference object. Ablation experiments with each module showed that SSPNet can better segment the GBM. The proposed method was also compared with the existing medical semantic segmentation model. The experimental results showed that the proposed method can obtain high-precision segmentation results for the GBM and completely segment the target. Finally, the thickness of the GBM was calculated using a skeleton extraction method to provide quantitative data for expert diagnosis. Full article

(This article belongs to the Section Biomedical Sensors)

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5 pages, 1336 KiB

Open AccessCase Report

Abdominal Pain Due to Liver Capsule Rupture: A Rare but Fatal Complication of Hepatocellular Carcinoma

by Haider Al Saadi, Reyam Al Zubaidi, Hervé O. Zender, Eric P. Heymann and Chiheb Said

Emerg. Care Med. 2025, 2(1), 13; https://doi.org/10.3390/ecm2010013 - 14 Mar 2025

Abstract

Background: Spontaneous rupture of the liver capsule secondary to the progression of hepatocellular carcinoma is a rare complication with high mortality. Case Description: This article presents the case of a 73-year-old male with no prior HCC diagnosis who presents acute abdominal pain and [...] Read more.

Background: Spontaneous rupture of the liver capsule secondary to the progression of hepatocellular carcinoma is a rare complication with high mortality. Case Description: This article presents the case of a 73-year-old male with no prior HCC diagnosis who presents acute abdominal pain and hemodynamic instability. Computed tomography reveals a heterogeneous liver lesion with capsular rupture and hemoperitoneum. Discussion: Management strategies focus on hemodynamic stabilization and bleeding control through transcatheter arterial embolization (TAE), surgical hemostasis or liver resection, the treatment selection is based on disease severity and patient condition. Conclusions: This case highlights the importance of considering HCC rupture in patients with acute abdominal pain and risk factors for liver disease, as early recognition and appropriate intervention significantly impact survival outcomes. Full article

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25 pages, 2740 KiB

Open AccessArticle

Genetic Response of Solanum lycopersicum L. (Tomato) to Phytophthora infestans and Aspergillus niger

by Tavershima Moses Anakaa, Odunayo Joseph Olawuyi and Segun Gbolagade Jonathan

Int. J. Plant Biol. 2025, 16(1), 35; https://doi.org/10.3390/ijpb16010035 - 14 Mar 2025

Abstract

There is limited information on the genetic response of tomato cultivars to pathogens. This study investigated the genetic mechanism of tomato that confers tolerance against Phytophthora infestans (Ph) and Aspergills niger (Asp) infection using different tomato accessions. Also, the [...] Read more.

There is limited information on the genetic response of tomato cultivars to pathogens. This study investigated the genetic mechanism of tomato that confers tolerance against Phytophthora infestans (Ph) and Aspergills niger (Asp) infection using different tomato accessions. Also, the study examined the effect of Ph and Asp infection on the morphology and the chromosome number of the infected tomatoes. Thirty tomato seed accessions were grown in a screen house, using a complete randomized design in triplicate, and evaluated for tolerance to both pathogens using a disease severity rating scale of 1 (highly tolerant) to 6 (highly susceptible), while chromosome assessment was performed using Carnoy’s protocol. Morphological data of 28 characteristics were collected using an IPGRI descriptor, while variance components, genetic advance (GA), and heritability were estimated for treated tomatoes and controls using the R statistical program. Accession NHT0254b, which was highly tolerant to Ph (1.00 ± 0.00) and Asp (1.33 ± 0.58), was diploid (2n = 2x = 24). The Ph-treated NHT0343a was moderately susceptible (3.67 ± 2.31), with 2n = 2x = 23, while NGB00711 was moderately susceptible (4.33 ± 1.16) with 2n = 2x = 22 after Asp treatment, indicating aneuploidy. In Ph treatment, cumulative fruit weight (CFW) had the highest environmental variance (1509.57), while number of seeds (NS) showed the highest genotypic variance (8.22). In Asp treatment, NS exhibited the highest genetic advance (2.97), while CFW had the highest phenotypic variance (754.91). Heritability estimates showed that fruit length (63.0%), the size of core (65.0%), and number of chambers (60.0%) were tolerant to Ph, while only fruit length (56.0%) was tolerant to Asp in terms of yield characteristics. Thus, tolerant accessions and traits are recommended for selection and genetic improvement. Full article

(This article belongs to the Section Plant–Microorganisms Interactions)

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20 pages, 528 KiB

Open AccessArticle

Advancing Photovoltaic Transition: Exploring Policy Frameworks for Renewable Energy Communities

by Francesca Giuliano and Andrea Pronti

Solar 2025, 5(1), 10; https://doi.org/10.3390/solar5010010 - 14 Mar 2025

Abstract

In the decarbonization process, the solar energy sector will play a crucial role, representing one of the key technologies for reducing greenhouse gas emissions. In Italy, photovoltaics stands out as the fastest-growing energy sector, thanks to the combination of favorable climatic conditions, supportive [...] Read more.

In the decarbonization process, the solar energy sector will play a crucial role, representing one of the key technologies for reducing greenhouse gas emissions. In Italy, photovoltaics stands out as the fastest-growing energy sector, thanks to the combination of favorable climatic conditions, supportive policies, and a growing interest in renewable energy sources. In this context, renewable energy communities (RECs) emerge as potential strategic tools for promoting the development of photovoltaics nationally and at the European level. Therefore, this study aims to examine the policy and regulatory frameworks governing RECs in Europe and Italy, highlighting their impact on the establishment, operation, and evolution of these communities. Through a critical analysis of legislative documents at both the European and national levels, this research identifies the key factors shaping the growth and functionality of RECs, such as governance structures, economic incentives, and social inclusivity. This study underscores the dual influence of comprehensive regulation and a certain degree of flexibility in fostering RECs’ adaptability to diverse contexts. Additionally, it identifies existing challenges, including regional implementation disparities, legal ambiguities, and potential conflicts with other renewable energy policies. The findings contribute to the ongoing discourse on decentralized energy systems, providing insights for policymakers to refine frameworks and maximize RECs’ contributions to sustainable energy transitions. Full article

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22 pages, 1495 KiB

Open AccessReview

Microbial Metallophores in the Productivity of Agroecosystems

by Lily X. Zelaya-Molina, Ismael F. Chávez-Díaz, José A. Urrieta-Velázquez, Marco A. Aragón-Magadan, Cristo O. Puente-Valenzuela, Mario Blanco-Camarillo, Sergio de los Santos-Villalobos and Juan Ramos-Garza

Microbiol. Res. 2025, 16(3), 67; https://doi.org/10.3390/microbiolres16030067 - 14 Mar 2025

Abstract

Microbial metallophores are low-molecular-weight chelating agents produced by microorganisms to acquire essential metal ions. Their biosynthesis, transport, and regulation involve complex processes, specialized enzymatic machinery, and intricate regulatory networks. This review examines the multifaceted roles of metallophores in microbial ecology and their potential [...] Read more.

Microbial metallophores are low-molecular-weight chelating agents produced by microorganisms to acquire essential metal ions. Their biosynthesis, transport, and regulation involve complex processes, specialized enzymatic machinery, and intricate regulatory networks. This review examines the multifaceted roles of metallophores in microbial ecology and their potential applications in sustainable agriculture, emphasizing their key role in trace metal acquisition, nutrient cycling, and plant–microbe interactions. Furthermore, it explores the potential applications of metallophores in agriculture, bioremediation, and biotechnology, connecting their potential to the development of novel strategies for sustainable agriculture. Full article

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24 pages, 852 KiB

Open AccessReview

Emerging Therapeutic Innovations for Vitiligo Treatment

by Weiran Li, Penghao Dong, Guiyuan Zhang, Junjie Hu and Sen Yang

Curr. Issues Mol. Biol. 2025, 47(3), 191; https://doi.org/10.3390/cimb47030191 - 14 Mar 2025

Abstract

Vitiligo is a chronic autoimmune disorder with a multifactorial etiology, typically manifesting as localized or generalized hypopigmentation or depigmentation of the skin and mucous membranes. The pathogenesis of vitiligo is complex and significantly impacts patients’ quality of life. Although traditional treatments such as [...] Read more.

Vitiligo is a chronic autoimmune disorder with a multifactorial etiology, typically manifesting as localized or generalized hypopigmentation or depigmentation of the skin and mucous membranes. The pathogenesis of vitiligo is complex and significantly impacts patients’ quality of life. Although traditional treatments such as hormone therapy, topical medications, and laser therapy can help control the disease to some extent, their outcomes remain unsatisfactory. Therefore, ongoing research is crucial to explore and develop novel treatment strategies while assessing their efficacy and safety. This review aims to classify and summarize various new candidate drugs for vitiligo currently undergoing clinical trials, providing a reference for clinical practice. Recent advancements in the understanding of the pathogenesis of vitiligo have facilitated the development of potential treatment strategies, such as Janus kinase inhibitors, cytokine blockers, and agents targeting tissue-resident memory or regulatory T cells. These emerging therapies offer hope to patients with vitiligo, though further investigation is needed to confirm their safety, efficacy, and optimal treatment regimens. Full article

(This article belongs to the Special Issue Molecular Research in Chronic Dermatoses, 2nd Edition)

17 pages, 3315 KiB

Open AccessReview

Efficiency and Applicability of Virtual Surgical Planning in Maxillofacial and Mandibular Bone Reconstruction: A Narrative Review

by Mohammed Mahmoud Shalabi, Khaldoun M. A. Darwich, Mohammad Naem Kheshfeh and Mohammad Younis Hajeer

Clin. Pract. 2025, 15(3), 62; https://doi.org/10.3390/clinpract15030062 - 14 Mar 2025

Abstract

Background: Facial structures are critical to aesthetics and function. Deformities can cause significant problems. Advances in surgical techniques, including three-dimensional (3D) computer simulation and virtual surgical planning (VSP), have improved outcomes. VSP accurately predicts surgical outcomes, revolutionizing facial reconstruction. This article reviews VSP [...] Read more.

Background: Facial structures are critical to aesthetics and function. Deformities can cause significant problems. Advances in surgical techniques, including three-dimensional (3D) computer simulation and virtual surgical planning (VSP), have improved outcomes. VSP accurately predicts surgical outcomes, revolutionizing facial reconstruction. This article reviews VSP in facial bone reconstruction, highlighting its advantages and accuracy over traditional methods. Methods: A systematic search using Medline (PubMed), Web of Science, Scopus, and Google Scholar revealed 1645 articles that addressed the topic of this study. Results: The systematic search yielded 64 articles that were highly relevant to the study objective, underscoring the critical importance of virtual surgical planning (VSP) in enhancing surgical precision and patient satisfaction. VSP has become a key player in improving surgical interventions and reducing complications, reinforcing its role as the preferred method in modern reconstructive surgery and thus improving functional and aesthetic outcomes, significantly enhancing patient satisfaction, and ensuring accurate interpretation of treatment plans. When compared to traditional surgical planning (TSP), VSP offers increased accuracy, shorter operating times, and superior aesthetic outcomes. Conclusions: VSP has been shown to effectively manage the complex challenges of facial anatomy and has significantly enhanced the planning and execution of reconstructive surgeries. This has been achieved by leveraging advanced imaging and computer-aided design. Full article

(This article belongs to the Special Issue New Trends, Materials, and Technologies and Consolidating Best Practices in Dentistry, 2nd Edition)

20 pages, 838 KiB

Open AccessSystematic Review

Obesity and Risk of Pre- and Postmenopausal Breast Cancer in Africa: A Systematic Review

by Najia Mane, Aya Fouqani, Siham Mrah, Majid Omari, Oumnia Bouaddi, Elodie Faure, El Mostafa El Fahime, Sihame Lkhoyaali, Saber Boutayeb, Karima El Rhazi, Chakib Nejjari, Inge Huybrechts and Mohamed Khalis

Curr. Oncol. 2025, 32(3), 167; https://doi.org/10.3390/curroncol32030167 - 14 Mar 2025

Abstract

Background and Aims: Several epidemiological studies have investigated the relationship between anthropometric factors and breast cancer (BC), but the results, particularly for premenopausal BC, remain inconsistent and contradictory. The aim of this systematic review is to present an overview of studies examining [...] Read more.

Background and Aims: Several epidemiological studies have investigated the relationship between anthropometric factors and breast cancer (BC), but the results, particularly for premenopausal BC, remain inconsistent and contradictory. The aim of this systematic review is to present an overview of studies examining the association between obesity and BC risk in African women, by menopausal status. Methods: PubMed, Scopus, Web of Science, and Google Scholar were searched until 17 February 2025 to identify published articles. The review included original studies, with no restrictions on publication date or language. The exposures studied were height, weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR). The quality of the studies was assessed using the National Institute of Health (NIH). Study selection and data extraction were carried out by two authors separately. Results: A total of fifteen case–control studies were included in this systematic review, comprising 45,056 subjects (7221 cases and 37,835 controls). Among them, fourteen studies reported stratified results for pre- and postmenopausal women, and one reported findings for only premenopausal BC. We found that BMI was associated with an increased risk of BC in both premenopausal and postmenopausal women, though the associations varied across studies. Height was associated with an increased risk of pre- and postmenopausal BC. WHR was positively associated with BC in pre- and postmenopausal women, while WC showed a positive association with the risk of postmenopausal BC, and inconsistent results with premenopausal BC. Finally, a higher HC was positively associated with premenopausal and postmenopausal BC. Conclusion: The risk of developing BC is higher in obese postmenopausal women. The protective role of BMI has not been demonstrated in African premenopausal women. WHR is a risk factor for premenopausal and postmenopausal BC. There is a need to study the influence of stages of overweight and obesity on BC risk in a large sample of African women in-depth. Full article

(This article belongs to the Section Breast Cancer)

28 pages, 718 KiB

Open AccessReview

Arterial Calcification as a Pseudoxanthoma Elasticum-like Manifestation in Beta-Thalassemia: Molecular Mechanisms and Significance

by Marialuisa Zedde and Rosario Pascarella

Hemato 2025, 6(1), 7; https://doi.org/10.3390/hemato6010007 - 14 Mar 2025

Abstract

Thalassemia, once associated with limited survival, now sees extended life expectancy due to treatment advancements, but new complications such as pseudoxanthoma elasticum (PXE)-like syndrome are emerging. In fact, thalassemia patients develop PXE-like features more frequently than the general population. These features include skin [...] Read more.

Thalassemia, once associated with limited survival, now sees extended life expectancy due to treatment advancements, but new complications such as pseudoxanthoma elasticum (PXE)-like syndrome are emerging. In fact, thalassemia patients develop PXE-like features more frequently than the general population. These features include skin lesions, ocular changes, and vascular issues like arterial calcifications, all linked to oxidative damage from iron overload. PXE-like syndrome in thalassemia mimics inherited PXE but is acquired. The underlying cause is thought to be oxidative stress due to iron overload, which induces free radicals and damages elastic tissues. Unlike inherited PXE, this form does not involve mutations in the ABCC6 gene, suggesting different pathogenic mechanisms, including abnormal fibroblast metabolism and oxidative processes. The vascular calcification seen in this syndrome often follows elastic fiber degeneration, with proteoglycans and glycoproteins acting as nucleation sites for mineralization. The condition can lead to severe cardiovascular and gastrointestinal complications. Studies have shown a significant incidence of PXE-like skin lesions in thalassemia patients, with some dying from cardiovascular complications. Research on ABCC6, a transporter protein involved in ectopic mineralization, has highlighted its role in various conditions, including PXE, beta-thalassemia, and generalized arterial calcification of infancy. ABCC6 mutations or reduced expression led to ectopic mineralization, affecting cardiovascular, ocular, and dermal tissues. The exact molecular mechanisms linking ABCC6 deficiency to ectopic mineralization remain unclear, though it is known to influence calcification-modulating proteins. This review focuses on the role of ABCC6 in the pathogenesis of calcifications, especially intracranial vascular calcifications in PXE and beta-thalassemia. Full article

9 pages, 1380 KiB

Open AccessArticle

Effect of ALS and 4-HPPD Inhibitor Herbicides on Maize Lines

by José I. Saavedra-Avila, J. Jesús García Zavala, Amalio Santacruz Varela, Fernando Castillo González and José Crossa

Crops 2025, 5(2), 10; https://doi.org/10.3390/crops5020010 - 14 Mar 2025

Abstract

Nicosulfuron and topramezone are herbicides with different mechanisms of action, and are recommended for weed control in maize (Zea mays L.). The objective of this study was to evaluate and compare the effect of both herbicides, at increasing doses of 0, 1× [...] Read more.

Nicosulfuron and topramezone are herbicides with different mechanisms of action, and are recommended for weed control in maize (Zea mays L.). The objective of this study was to evaluate and compare the effect of both herbicides, at increasing doses of 0, 1× and 3×, equivalent to 0, 60, and 180 g ai ha⁻¹ for nicosulfuron, and 0, 33.6, and 100.8 g ai ha⁻¹ for topramezone, on physiological and agronomic characteristics in 29 maize lines, including S₂, S₃ and S₄, using an alpha-lattice incomplete block design. The cluster analysis divided our genotypes into two groups for both herbicides, based on their higher or lower fresh weight. The results showed a reduction in the SPAD index for both herbicides at 7 days after application, and nicosulfuron caused a reduction in the green matter weight of 33.4%. Similarly, nicosulfuron caused a delay and a reduction in its doses, after an initial increase, for all the agronomic variables, female flowering (FF), male flowering (MF), plant height (PH), ear height (EH), and grain weight (GW), in doses of 60 and 180 g ai ha⁻¹, while topramezone only affected PH (1×–3×) and EH (3×). When comparing the applications of both herbicides on the maize genotypes, a difference in female and male flowering of 5.09 and 4.86 days, respectively was observed. A differential response and greater damage to nicosulfuron were observed in maize genotypes, with respect to topramezone applications. Full article

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28 pages, 17094 KiB

Open AccessArticle

Innovative Elaboration of Polyvinylidene Fluoride Thin Films via Dip-Coating: Beta Phase Optimization, Humidity Control, Nanoparticles Addition, and Topographic Analysis

by Marwan Fakhry, Olivier Soppera and Dominique Berling

Micro 2025, 5(1), 12; https://doi.org/10.3390/micro5010012 - 14 Mar 2025

Abstract

Polyvinylidene fluoride (PVDF) is a multifunctional polymer renowned for its unique electrical, mechanical, and piezoelectric properties, making it an attractive candidate for various applications. Although the spin-coating method has been the conventional method for fabricating PVDF thin films, this work is the first [...] Read more.

Polyvinylidene fluoride (PVDF) is a multifunctional polymer renowned for its unique electrical, mechanical, and piezoelectric properties, making it an attractive candidate for various applications. Although the spin-coating method has been the conventional method for fabricating PVDF thin films, this work is the first to apply the dip-coating technique with humidity control, which is a largely unexplored method in the literature on PVDF thin films. This novel approach offers great prospects for improved control and performance adjustments, as well as expanding the range of film deposition procedures. Here, we examine the phase composition of PVDF thin films; adjust different parameters to optimize the electroactive phases fraction, especially the Beta phase; and examine how relative humidity affects the properties of the film. Moreover, we test the impact of different nanoparticles’ addition on the phases fraction and characteristics of the film. Furthermore, we analyze the topography of the resultant films using several approaches, providing fresh insights into their structural features. Full article

(This article belongs to the Special Issue Advances in Micro- and Nanomaterials: Synthesis and Applications)

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21 pages, 1943 KiB

Open AccessArticle

Effects of Sinensetin, Eupatilin, and Jaceosidin on Human Melanogenesis: A Pilot Study

by Shilpi Goenka

Future Pharmacol. 2025, 5(1), 12; https://doi.org/10.3390/futurepharmacol5010012 - 14 Mar 2025

Abstract

Background/Objectives: Flavones, a class of plant-based flavonoids, have demonstrated conflicting anti-melanogenic activities in mouse and human melanocytes. Sinensetin (SNT), a polymethoxyflavone, has shown pro-melanogenic activity in B16F10 mouse melanoma (MM) cells, while eupatilin (EU) and jaceosidin (JAC), two flavones that are structural analogs [...] Read more.

Background/Objectives: Flavones, a class of plant-based flavonoids, have demonstrated conflicting anti-melanogenic activities in mouse and human melanocytes. Sinensetin (SNT), a polymethoxyflavone, has shown pro-melanogenic activity in B16F10 mouse melanoma (MM) cells, while eupatilin (EU) and jaceosidin (JAC), two flavones that are structural analogs of SNT, have not been evaluated for their effects on melanogenesis yet. Methods: Herein, the effects of SNT, EU, and JAC on melanogenesis in MNT-1 cells (human melanoma) and HEMn-DP cells (primary human melanocytes) have been examined. The mushroom tyrosinase (TYR) activity was tested in cell-free conditions, followed by examination of the cytotoxicity of the compounds via the Alamar Blue (AB) assay. Cellular melanin production and TYR activity were estimated in MNT-1 cells. The compounds were further examined in primary human melanocytes for melanin production, TYR activity, and protein levels. Results: Our findings show that SNT was a potent inhibitor of TYR activity in a cell-free assay, while EU and JAC had no effect. However, both SNT and EU were shown to exhibit anti-melanogenic activity (that was reversible) in human cells, while JAC was ineffective and cytotoxic. Conclusions: SNT and EU are potential novel candidates for hyperpigmentation treatment without cytotoxicity. Additional studies are warranted to elucidate the signaling mechanisms that govern their anti-melanogenesis action. Future research is necessary to assess the anti-melanogenic effectiveness of SNT/EU using 3D skin tissue equivalents and to select the optimal candidate. Full article

28 pages, 2534 KiB

Open AccessArticle

Assessment of Service Quality and Trust of E-Public Transportation in Doha Qatar

by Larry C. Flores, Ardvin Kester S. Ong, Roberto Andrew G. Roque IV, Terrence Manuel C. Palad, John Dave D. Concepcion and Rommualdo D. Aguas, Jr.

World Electr. Veh. J. 2025, 16(3), 174; https://doi.org/10.3390/wevj16030174 - 14 Mar 2025

Abstract

This study examined the relationship between service quality, trust, and passenger satisfaction in sustainable e-public transportation, using the Doha Metro in Qatar as a case study. Despite its advanced automation, the metro faces low adoption, with less than 30% of the economically active [...] Read more.

This study examined the relationship between service quality, trust, and passenger satisfaction in sustainable e-public transportation, using the Doha Metro in Qatar as a case study. Despite its advanced automation, the metro faces low adoption, with less than 30% of the economically active population utilizing it. To address this, this study integrated the Social Exchange Theory (SET) and the SERVQUAL RATER model with machine learning techniques to assess commuter perceptions and satisfaction. Neural network and Long Short-Term Memory (LSTM) models outperformed traditional statistical methods, offering enhanced predictive accuracy. Based on the 319 survey responses, key service quality factors were identified, emphasizing customer experience (NI = 100.0%), security (NI = 99.9%), and service reliability (NI = 90.8%). Findings suggested that improving affordability and dynamic pricing could increase metro ridership while reducing private vehicle reliance. Additionally, predictive maintenance and crisis management strategies are recommended to enhance service reliability. This study contributes to sustainable urban mobility by providing data-driven recommendations for efficient and environmentally friendly e-public transportation. Policymakers and urban planners can utilize these insights to improve commuter satisfaction and transit system adoption. Future research may explore multi-city comparisons and hybrid modeling techniques for further refinement. Full article

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13 pages, 428 KiB

Open AccessArticle

Developmental Language Disorder at Adolescence: Links Between Communication Skills and Self-Efficacy Ratings

by Anabel Buteau-Poulin, Nancy Gaudreau and Chantal Desmarais

Disabilities 2025, 5(1), 30; https://doi.org/10.3390/disabilities5010030 - 14 Mar 2025

Abstract

Developmental Language Disorder (DLD) has a prevalence of 7%, making it one of the important yet little known neurodevelopmental disorders. Often identified in kindergarten, children with DLD have language learning difficulties severe enough to impact their schooling and socialization. During adolescence, there is [...] Read more.

Developmental Language Disorder (DLD) has a prevalence of 7%, making it one of the important yet little known neurodevelopmental disorders. Often identified in kindergarten, children with DLD have language learning difficulties severe enough to impact their schooling and socialization. During adolescence, there is a high risk of academic, vocational, and mental health difficulties. However, for adults with DLD, a positive perception of self-efficacy may act as a protective factor. This led us to explore how communications skills and self-efficacy are related in adolescents with DLD. The participants were 49 teenagers, aged 12 to 15, who have DLD. Communication was measured using the Children’s Communication Checklist, completed by the teenagers’ parents, while perception of self-efficacy was reported by the teenagers as well as by their parents using the Generalized Self-Efficacy Scale. A significant correlation was found between communication and self-efficacy with three domains of communication being the most important in this association, i.e., coherence (r = 0.716, p < 0.001), initiation (r = 0.581, p < 0.001), and use of context (r = 0.649, p < 0.001). These results highlight the crucial role of social communication in the profile of teenagers living with DLD. They further suggest that it may be relevant to examine whether supporting language development may foster positive perception of self-efficacy in teenagers living with DLD. Full article

20 pages, 6466 KiB

Open AccessArticle

MSFNet3D: Monocular 3D Object Detection via Dual-Branch Depth-Consistent Fusion and Semantic-Guided Point Cloud Refinement

by Rong Yang, Zhijie You and Renhui Luo

World Electr. Veh. J. 2025, 16(3), 173; https://doi.org/10.3390/wevj16030173 - 14 Mar 2025

Abstract

The rapid development of autonomous driving has underscored the pivotal role of 3D perception. Monocular 3D object detection, as a cost-effective alternative to expensive lidar systems, is garnering increasing attention. However, existing pseudo-lidar methods encounter challenges such as coarse quality and insufficient semantic [...] Read more.

The rapid development of autonomous driving has underscored the pivotal role of 3D perception. Monocular 3D object detection, as a cost-effective alternative to expensive lidar systems, is garnering increasing attention. However, existing pseudo-lidar methods encounter challenges such as coarse quality and insufficient semantic information when generating 3D point clouds from monocular images. To address these issues, this paper introduces MSFNet3D, which aims to overcome the quality limitations of pseudo-lidar point cloud. Our contributions are threefold: (1) We introduce a dual-branch network to optimize depth maps and propose a multi-scale channel spatial attention module (MS_CBAM). This module captures multi-scale geometric features through a hierarchical feature pyramid and an adaptive weight allocation mechanism, thereby addressing the scale sensitivity inherent in traditional attention mechanisms. (2) We propose a consistency-weighted fusion strategy that employs local gradient consistency analysis and differentiable weighted optimization to achieve a pixel-level fusion of image and depth features. This approach reduces feature conflicts within the dual-branch network and enhances the model’s robustness in complex scenes. (3) We introduce a semantic-guided pseudo-point cloud enhancement method that leverages an instance segmentation network to extract object-specific semantic regions and generate high-confidence point cloud, consequently improving the accuracy of object detection. Experiments on the KITTI dataset show that the proposed method performs excellently under various detection challenges, achieving an average precision of 18.87% in the 3D detection of car objects, which is a 1.67% improvement over the original model. The method also shows good performance in detecting pedestrians and cyclists. The proposed framework can provide economical and reliable 3D perception for mass-produced electric vehicles. Full article

(This article belongs to the Special Issue Vehicle-Road Collaboration and Connected Automated Driving)

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21 pages, 4295 KiB

Open AccessArticle

Estimation of Vehicle Mass and Road Slope for Commercial Vehicles Utilizing an Interacting Multiple-Model Filter Method Under Complex Road Conditions

by Gang Liu

World Electr. Veh. J. 2025, 16(3), 172; https://doi.org/10.3390/wevj16030172 - 14 Mar 2025

Abstract

Precise and real-time estimation of vehicle mass and road slope plays a pivotal role in attaining accurate vehicle control. Currently, road slope estimation predominantly emphasizes longitudinal slopes, with limited research on intricate slopes that include both longitudinal roads and continuous turning up-and-down slopes. [...] Read more.

Precise and real-time estimation of vehicle mass and road slope plays a pivotal role in attaining accurate vehicle control. Currently, road slope estimation predominantly emphasizes longitudinal slopes, with limited research on intricate slopes that include both longitudinal roads and continuous turning up-and-down slopes. To address the limitations in existing road slope estimation research, this paper puts forward a novel joint-estimation approach for vehicle mass and road slope. Vehicle mass is initially estimated via M-estimation and recursive least squares with a forgetting factor (FFRLS). A road slope estimate approach, which utilizes interacting multiple models (IMM) and cubature Kalman filtering (CKF), is proposed for complex road slope scenarios. This algorithm integrates kinematic and dynamic vehicle models within the multi-model (MM) ensemble of the IMM filter. The kinematic vehicle model is appropriate for longitudinal road gradients, whereas the dynamic vehicle model is better suited for continuous turning up-and-down slope conditions. The IMM filter employs a stochastic process to weight the appropriate vehicle model according to the driving conditions. Consequently, the weights assigned by the IMM filter enable the algorithm to adaptively select the most suitable vehicle model, leading to more accurate slope estimates under complex conditions compared to single-model-based algorithms. Simulations were carried out using Matlab/Simulink2020-Trucksim2020 to verify the effectiveness of the proposed estimation approach. The results demonstrate that, compared with existing methods, the proposed estimation approach has achieved an improvement in the precision of evaluating vehicle mass and road gradient, thus confirming its superiority. Full article

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16 pages, 956 KiB

Open AccessArticle

Effects of a Postural Hammock in People with Chronic Neck Pain and Chronic Low Back Pain: A Randomized Controlled Trial

by José Manuel Delfa-De-La-Morena, Juan-José Mijarra-Murillo, Víctor Navarro-López and Diego Fernández-Vázquez

Medicina 2025, 61(3), 502; https://doi.org/10.3390/medicina61030502 - 14 Mar 2025

Abstract

Background and Objectives: Musculoskeletal disorders (MD) affect over 1.7 billion people worldwide, with neck and low back pain being prevalent and debilitating conditions. Current treatments include various interventions, but novel approaches are needed to improve functionality and reduce disability. To evaluate the [...] Read more.

Background and Objectives: Musculoskeletal disorders (MD) affect over 1.7 billion people worldwide, with neck and low back pain being prevalent and debilitating conditions. Current treatments include various interventions, but novel approaches are needed to improve functionality and reduce disability. To evaluate the effects of a postural hammock on pain and functionality in people with chronic neck and low back pain. Materials and Methods: A randomized controlled trial was conducted with participants experiencing chronic neck and/or low back pain. They were assigned to either an experimental group using a postural hammock or a control group lying on a mat. Participants underwent five sessions of 10 min each over five consecutive days. Results: Forty-three subjects completed the study. While both groups showed improvements, the experimental group exhibited significant increases in hamstring flexibility and pain tolerance, measured through the Visual Analog Scale (VAS) and pressure pain thresholds (PPT). Postural hammock use demonstrated potential benefits in pain management and flexibility compared to conventional methods. Conclusions: Using a postural hammock may offer benefits for individuals with chronic back pain. Future research should explore combining hammock therapy with other interventions to enhance outcomes and improve the quality of life for patients with back pain. Full article

(This article belongs to the Section Orthopedics)

29 pages, 3120 KiB

Open AccessReview

Advancing Urban Development: Applications of Hyperspectral Imaging in Smart City Innovations and Sustainable Solutions

by Arvind Mukundan, Riya Karmakar, Jumana Jouhar, Muhamed Adil Edavana Valappil and Hsiang-Chen Wang

Smart Cities 2025, 8(2), 51; https://doi.org/10.3390/smartcities8020051 - 14 Mar 2025

Abstract

Smart cities are urban areas that use advanced technologies to make urban living better through efficient resource management, sustainable development, and improved quality of life. Hyperspectral imaging (HSI) is a noninvasive and nondestructive imaging technique that is revolutionizing smart cities by offering improved [...] Read more.

Smart cities are urban areas that use advanced technologies to make urban living better through efficient resource management, sustainable development, and improved quality of life. Hyperspectral imaging (HSI) is a noninvasive and nondestructive imaging technique that is revolutionizing smart cities by offering improved real-time monitoring and analysis capabilities across multiple urban sectors. In contrast with conventional imaging technologies, HSI is capable of capturing data across a wider range of wavelengths, obtaining more detailed spectral information, and in turn, higher detection and classification accuracies. This review explores the diverse applications of HSI in smart cities, including air and water quality monitoring, effective waste management, urban planning, transportation, and energy management. This study also examines advancements in HSI sensor technologies, data-processing techniques, integration with Internet of things, and emerging trends, such as combining artificial intelligence and machine learning with HSI for various smart city applications, providing smart cities with real-time, data-driven insights that enhance public health and infrastructure. Although HSI may generate complex data and tends to cost much, its potential to transform cities into smarter and more sustainable environments is vast, as discussed in this review. Full article

(This article belongs to the Special Issue Digital Innovation and Transformation for Smart Cities)

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15 pages, 2843 KiB

Open AccessArticle

Study on Stone Blocks Used for Resthouses Along the Northwest Royal Road Connecting Angkor in Cambodia and Phimai in Thailand Based on On-Site Magnetic Susceptibility Measurements and Chemical Composition Analyses

by Etsuo Uchida, Yoshimitsu Kobayashi, Aoi Mizumori, Kaito Kuriyama and Keishiro Azami

Heritage 2025, 8(3), 106; https://doi.org/10.3390/heritage8030106 - 14 Mar 2025

Abstract

The purpose of this paper was to identify the types of stone used in the “Resthouses” along the Northwest Royal Road connecting Angkor in Cambodia and Phimai in Thailand and to determine their sources through magnetic susceptibility measurements and chemical composition analyses. Laterite [...] Read more.

The purpose of this paper was to identify the types of stone used in the “Resthouses” along the Northwest Royal Road connecting Angkor in Cambodia and Phimai in Thailand and to determine their sources through magnetic susceptibility measurements and chemical composition analyses. Laterite was the primary building material for the “Resthouses”, except for Pr. Ku Sila Khan in Thailand. Pr. Ku Sila Khan, located at the northernmost point of the Northwest Royal Road, was primarily built with fine-grained red sandstone. Based on the magnetic susceptibility and the V, Sr, and As contents of the laterite, the following pairs of “Resthouses” were likely sourced from the same quarries: Pr. Sampov and Pr. Saman Teng, Pr. Kok Ac Chring and Pr. Kok Mon, Pr. Ta Muan and Pr. Thamo, and Pr. Ban Bu and Pr. Non Kong. Fine-grained red sandstone, white siliceous sandstone, red siliceous sandstone, and gray sandstone were used for the frame material of the openings. The Rb vs. Ti diagram and magnetic susceptibility measurements suggest that the fine-grained red sandstone and siliceous white sandstone used in the “Resthouses” in Thailand were likely sourced from the Khok Kruat Formation and the Phu Phan Formation, respectively. However, the red siliceous sandstone and white siliceous sandstone used in the “Resthouses” in Cambodia are presumed to have been sourced from the Sao Khua Formation and the Phra Wihan Formation, respectively. Gray sandstone from the Phu Kradung Formation was uniquely used in the frame material of the openings of Pr. Sampov and Pr. Kok Mon in Cambodia. In conclusion, the sandstone used in the door and window frames of the “Resthouses” appears to have been determined by the surrounding geology. Laterite was used as the primary building material for the “Resthouses” along the Northwest Royal Road, whereas valuable sandstone was used for those along the East Royal Road. This suggests that the Northwest Royal Road was of lesser importance compared to the East Royal Road. Full article

(This article belongs to the Section Architectural Heritage)

15 pages, 499 KiB

Open AccessReview

Overview of Radiological Reporting and Data System (RADS) Guidelines Currently Applicable in Surgery

by Marco Parillo and Carlo Cosimo Quattrocchi

Surgeries 2025, 6(1), 23; https://doi.org/10.3390/surgeries6010023 - 14 Mar 2025

Abstract

Standardized frameworks for interpreting medical images, such as the radiological Reporting and Data Systems (RADS), are designed to improve the consistency and accuracy of radiological assessments across different imaging modalities, anatomical locations, and disease processes. Clear communication and information sharing between radiologists and [...] Read more.

Standardized frameworks for interpreting medical images, such as the radiological Reporting and Data Systems (RADS), are designed to improve the consistency and accuracy of radiological assessments across different imaging modalities, anatomical locations, and disease processes. Clear communication and information sharing between radiologists and referring physicians, including surgeons, is a key goal of the RADS guidelines. Therefore, familiarity with these guidelines is crucial for all physicians involved in patient care. This review synthesizes current RADS guidelines relevant to surgical practice. Our analysis identified 28 radiological RADS with potential applications in surgical workflows, primarily in oncology. Of the RADS examined, nine were validated by the American College of Radiology (ACR), one was validated through a collaboration between the ACR and other scientific societies, and seventeen were developed by other scientific organizations. Numerous surgical specialties may encounter RADS in clinical practice, including neurosurgery, head and neck surgery, cardiovascular surgery, thoracic surgery, endocrine surgery, breast surgery, gastrointestinal surgery, hepatobiliary surgery, gynecological surgery, urological surgery, orthopedic surgery, emergency surgery, and surgical oncology. The effective utilization and validation of RADS necessitates close collaboration between radiologists and surgeons, coupled with widespread education for all healthcare professionals involved in patient care. Artificial intelligence software will play an important role in facilitating the dissemination and use of RADS in clinical practice. Full article

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